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KMID : 0380620140460040489
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 4 p.489 ~ p.497
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Effects of Unripe Black Raspberry Water Extract on Lipid Metabolism and Oxidative Stress in Mice
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Choi Hye-Ran
Lee Jung-Hyun
Lee Su-Jung
Lee Min-Jung
Jeong Jong-Tae
Lee Tae-Bum
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Abstract
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We examined the effects of unripe black raspberry water extract (UBR-W) on lipid metabolism and oxidative stress in mice. C57BL/6J mice were divided into 4 groups: those administered a control diet (CTL), high-fat diet (HFD), UBR-W and simvastatin for 12 weeks. In the HFD group, LDL cholesterol were significantly higher than in the CTL group. However, the UBR-W treated group showed dose-dependent reduction of plasma LDL levels. Hepatic total lipid, TC, and malondialdehyde were significantly increased in hyperlipidemic mice. However, supplementation with either UBRW or simvastatin effectively reduced these lipid profiles and lipid peroxidation. UBR-W increased mRNA expression of the LDL receptor, sterol regulatory element binding protein 2 (SREBP2), 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and ATP-binding cassette transporter A1 (ABCA1) compared to that observed in the HFD group. In addition, UBR-W and simvastatin showed significantly reduced oxidized LDL uptake by the scavenger receptor CD36. These results suggest that UBR-W is useful for treatment and prevention of hyperlipidemia and lipid peroxidation.
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KEYWORD
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Unripe black raspberry, High-fat diet, Hyperlipidemia, Lipid metabolism, Oxidative stress
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